Fri Dec 23 2022

18 articles - From Friday Dec 16 2022 to Friday Dec 23 2022

parm_toc.knit

Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

J Crohns Colitis

ECCO Guidelines on Inflammatory Bowel Disease and Malignancies.

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Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Inflamm Bowel Dis

The Clinical Response of Upadacitinib and Risankizumab Is Associated With Reduced Inflammatory Bowel Disease Anti-TNF-a Inadequate Response Mechanisms.

Collectively, these data suggest that upadacitinib and risankizumab affect TNF-IR upregulated mechanisms, which may account for their clinical response among TNF-IR IBD patients.

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The Oral-Gut Axis: Periodontal Diseases and Gastrointestinal Disorders.

As such, oral microbiota dysbiosis involving specific bacteria, including Fusobacterium nucleatum and Porphyromonas gingivalis, can ultimately lead to gut malignancies. Further understanding the precise mechanism(s) of the oral-gut microbial axis in PD, IBD, and colorectal cancer pathogenesis will be pivotal in diagnosis, prognosis, and future treatment.

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J Crohns Colitis

Diet Quality and Risk of Older-Onset Crohn's Disease and Ulcerative Colitis.

Interpretation We found that several healthy eating patterns were associated with a lower risk of older-onset CD. Our findings provide a rationale for adapting different healthy dietary patterns based on individuals' food preferences and traditions for designing future prevention strategies for IBD.

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Exposure to thioguanine during 117 pregnancies in women with inflammatory bowel disease.

In this large case series the use of thioguanine during pregnancy is not associated in excess with adverse maternal or neonatal outcomes.

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Mucosal addressin cell adhesion molecule 1 expression reflects mucosal inflammation and subsequent relapse in patients with ulcerative colitis.

MAdCAM-1 expression in the colonic mucosa of UC patients related to mucosal inflammation and subsequent relapse; it may serve as a marker for both relapse and therapeutic effectiveness in UC.

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RNA editing is a valuable biomarker for predicting carcinogenesis in ulcerative colitis.

The risk of CAN can be evaluated by assessing ADAR1 expression in the rectum of MES0 UC patients, freeing UC patients from unnecessary colonoscopy and reducing their physical burden. RNA editing may be involved in UC carcinogenesis, and may be used to facilitate the prevention and treatment of CAN in UC.

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Transmural remission characterized by high biologic concentrations demonstrates better prognosis in Crohn's disease.

Transmural remission was the best predictor for prognosis in CD patients who received maintenance biologic therapy. High drug concentration levels were associated with transmural remission confirmed via MRE.

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Pancreatology

Acute pancreatitis is characterized by generalized intestinal barrier dysfunction in early stage.

Patients with AP have significant disturbances in intestinal barrier structure and function in first 2 weeks from onset that persist despite institution of enteral nutrition.

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Diagnostic performance of endoscopic ultrasound elastography for differential diagnosis of solid pancreatic lesions: A propensity score-matched analysis.

We provided the optimal cut-off SR values for differential diagnosis between MFP and PDAC. EUS-EG can be used as a supplementary diagnostic method in the diagnosis of SPLs. (Clinical trial registration

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Optimising the measurement of intra-bladder pressure in patients with predicted severe acute pancreatitis.

In predicted SAP patients, measuring IBP at the iliac crest with HoBE15 after instilling 10 mL of NS seems to be appropriate for monitoring IAP.

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Outcome after surgery for invasive intraductal papillary mucinous neoplasia compared to conventional pancreatic ductal adenocarcinoma - A Swedish nationwide register-based study.

In this population-based nationwide study, outcome after resected inv-IPMN compared to PDAC is more favourable in lower stages, and similar to worse in higher.

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Presumed radiological diagnosis of solid pseudopapillary tumors: do we really know what we are watching?

There is a broad disease spectrum mimicking SPT at CT and MRI. Key imaging features, clinical information and laboratory findings must be integrated to improve the diagnostic accuracy.

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The M-ANNHEIM-AiP-Activity-Score is useful for predicting relapse in patients with type 1 autoimmune pancreatitis.

MAAS is useful for predicting relapse in patients with type 1 AIP undergoing maintenance therapy.

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The phase 1/2 trial of indomethacin in chronic pancreatitis (The PAIR trial): Protocol for a parallel multi-center randomized controlled trial.

Background/objectives Current treatments for chronic pancreatitis focus on symptom management and therapeutics targeting disease reversal are lacking. Given the role of the cyclooxygenase-2 (COX-2) enzyme in producing prostaglandin E levels, this may represent a potential disease-altering treatment for chronic pancreatitis.

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The PRSS3P2 and TRY7 deletion copy number variant modifies risk for chronic pancreatitis.

The common PRSS3P2 and TRY7 deletion CNV was associated with a reduced risk for CP. This finding provides additional support for the emerging view that dysregulated PRSS2 expression represents a discrete mechanism underlying CP predisposition or protection.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link


Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Inflamm Bowel Dis

Environmental Interaction of Resolved Human Cytomegalovirus Infection With Crohn's Disease Location.

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Helicobacter pylori and Inflammatory Bowel Disease: An Unresolved Enigma.

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Letters&Replies

Letters to the editors and authors’ replies